According to THR, McGuire was born on March 20, 1926, in Bridgeport, Connecticut. In the ’50s, the actor had roles in Broadway productions of Plain And Fancy, Happy Hunting, and Oh Captain! She earned her first TV and film credits in the ’70s, and went on to appear on shows like Charlie’s Angels, Lou Grant, Matlock, St. Elsewhere, and MacGyver. She notably played the on-screen mother of Joanna Kerns’ Maggie and the Seaver kids’ grandma on the ABC sitcom Growing Pains. McGuire appeared on 12 episodes throughout the show’s seven-season run from 1985 to 1992. She also appeared in films including Coma, Up In Smoke, The Incredible Shrinking Woman, Wishmaster, and Inside. Later in her career, she guest-starred on CSI: Miami and ER.
McGuire was an active member of her retirement community and, in a 2019 interview with NBC Nightly News, expressed enthusiasm at 92 for producing a Channel 22 interview show called GabFest. She reportedly served as a receptionist and advocate for the Coalition for Economic Survival, an organization that fights for tenants’ rights. According to THR, McGuire has no survivors.