Read this: The origins of the "sad blob" from those early '00s Zoloft commercials
Animator Patrick Smith created an ad whose cartoon character embodied the effects of depression

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It’s tough out there for a cartoon blob. Screenshot: SuperBowlSammy
Though it has plenty of tough competition, the “sad blob” from those early 2000s Zoloft TV commercials stands (or slumps) strong among the surprisingly stiff competition that is the canon of horribly depressed cartoon characters. In order to figure out how this famously miserable egg-thing came to be—and the role it played in normalizing discussions of mental illness in popular culture— Mel Magazine looked into the advertisement’s history.