Will Smith confirms that the I Am Legend sequel is using the non-canonical DVD ending
Remember I Am Legend? The sequel is hoping you don't

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I Am Legend Screenshot: YouTube
When news came out last year that Will Smith and Michael B. Jordan were working on a sequel to Smith’s 2007 movie I Am Legend, pedantic movie nerds (like us, okay?) pointed out that Will Smith’s character died in the original movie—one of the main things that generally prevents a character from appearing in a sequel. However, as we pedantically noted at the time, the I Am Legend DVD contained an alternate ending that was a little more faithful to Richard Matheson’s original book, where Smith’s character lived and had to endure the realization that he had become a monster in the eyes of the vampire-zombies that had taken over Manhattan.