Jeremy Irons (Rodrigo Borgia)François Arnaud (Cesare Borgia)Holliday Grainger (Lucrezia Borgia)Peter Sullivan (Cardinal Ascanio Sforza)Sean Harris (Micheletto)Joanne Whalley (Vanozza Cattaneo)Lotte Verbeek (Giulia Farnese)Colm Feore (Giuliano Della Rovere)Vernon Dobtcheff (Cardinal Versucci)David Oakes (Juan Borgia)Bosco Hogan (Cardinal Piccolomini)Gina McKee (Caterina Sforza)David Alpay (Calvino)Julian Bleach (Niccolo Machiavelli)Sebastian De Souza (Alfonso of Aragon)Thure Lindhardt (Rufio)Steven Berkoff (Girolamo Savonarola)Ruta Gedmintas (Ursula Bonadeo)
The rise to power, and start of a dynasty, of the Borgia family. Rodrigo Borgia ascends within the Catholic Church, becoming Pope Alexander VI. The position brings with it many enemies, internal and state-based, and he has to use all of his abilities of diplomacy, ruthlessness, charm, and the power of the church to stay in power, and alive. Luckily, his children are equally ambitious.