Rachel Bilson (Dr. Zoe Hart)Jaime King (Lemon Breeland)Cress Williams (Lavon Hayes)Wilson Bethel (Wade Kinsella)Scott Porter (George Tucker)Tim Matheson (Dr. Brick Breeland)Kaitlyn Black (AnnaBeth Nass)Ross Philips (Tom Long)Mallory Moye (Wanda Long)Reginald VelJohnson (Dash DeWitt)Brandi Burkhardt (Crickett)Claudia Lee (Magnolia Breeland)Matt Lowe (Meatball)John Eric Bentley (Sheriff Bill)Armelia McQueen (Shula)Mircea Monroe (Tansy Truitt)Laura Bell Bundy (Shelby Sinclair)Steven M. Porter (Frank Moth)
Fast-talking New Yorker and brand-new doctor Zoe Hart has it all figured out: after graduating top of her class from medical school, she'll follow in her father's footsteps and become a cardio-thoracic surgeon. But when her dream falls apart, Zoe decides to accept an offer from a stranger, Dr. Harley Wilkes, to work with him at his small practice in Bluebell, Alabama. Zoe arrives in this small Gulf Coast town only to find that Harley has passed away and left his half of the medical practice to her in his will.