Julia Louis-Dreyfus (Christine Campbell)Clark Gregg (Richard Campbell)Hamish Linklater (Matthew Kimble)Trevor Gagnon (Ritchie Campbell)Emily Rutherfurd (Christine 'New Christine' Hunter)Tricia O'Kelley (Marly Ehrhardt)Alex Kapp (Lindsay)Wanda Sykes (Barb Baran)Lily Goff (Ashley Ehrhardt)Marissa Blanchard (Kelsey)Blair Underwood (Daniel Harris)Mary Beth McDonough (Mrs. Wilhoite)Michaela Watkins (Lucy)Jordan Baker (Mrs. Belt)Eric McCormack (Dr. Max Kershaw)Nancy Lenehan (Principal Marcie Nunley)Matt Letscher (Burton Schaefer)Scott Bakula ('Papa Jeff' Hunter)
Christine is divorced from Richard but continues to see him as a best friend, even when he becomes involved with a woman, also named "Christine." Living in an apartment with her son Ritchie, her brother Matthew rents a separate room in an outbuilding and the two of them feed off the insecurities of the other implanted by their mother during their upbringing. "Old" Christine runs a gym with her best friend Barb, whose name describes her wit. Christine's insecurities are not helped by the other parents at a posh school she and Richard send their son to, one that is generally thought to be beyond the means of regular working people.