Selma Blair (Zoe Bean)Michael Rosenbaum (Jack Cooper)Azura Skye (Jane Cooper)David Moscow (Duncan Milch)Mary Page Keller (Iris Bean)Sara Rue (Breeny)Jacinda Barrett (Lisa)Amy Aquino (Mrs. Milch)Hamilton von Watts (Andy)Erik Aude (Norb Schaffer)Richard Joel (Customer #2)Nancy Lenehan (Mrs. Needles)Tamara Mello (Angela)Will Friedle (Jeremy Pinter)Scott Foley (Montana Kennedy)Simon Templeman (D'Art)Tamara Braun (Anna)Alexander Enberg (Nigel)
Pete Aronson, Robert Bradley, Emily Cutler, James L. Freedman, Michael Grodner, Darin Henry, Michael Langworthy, Stacie Lipp, Phil Lord, Jeff Lowell, Nora Lynch, Christopher Miller, Kendra Mora, Scott Murphy, Matthew Nelson, Daniel Paige, Sue Paige, Phil Palisoul, Roger Reitzel, Michael Rowe, J.J. Wall, David Kirkwood
Zoe, Duncan, Jack & Jane is a series that saw two lives. First: The first series follows four students (see title of show) at a private high school, Fielding Mellish Prep, in Manhattan. Even in the first series, the show focus was on Zoe (the other kids in the title are friends of Zoe's (Selma Blair), the twins Jack (a pre-Lex Luthor Michael Rosenbaum) and Jane (Azura Skye), and the loser Duncan (David Moscow)). The first series lasted 13 episodes before being halted for a remix. Second: The second series was just called "Zoe" and follows Zoe a few years later as a college student studying psychology. Most of the characters from the first 13 episodes, turn up in the second "Zoe" 13 episodes.