Seth MacFarlane (Capt. Ed Mercer)Adrianne Palicki (Cmdr. Kelly Grayson)Penny Johnson Jerald (Dr. Claire Finn)Scott Grimes (Lt. Gordon Malloy)Peter Macon (Lt. Cmdr. Bortus)J. Lee (Lt. Cmdr. John LaMarr)Mark Jackson (Isaac)Norm MacDonald (Yaphit)Jessica Szohr (Lt. Talla Keyali)Chad L. Coleman (Klyden)Halston Sage (Lt. Alara Kitan)Victor Garber (Admiral Halsey)BJ Tanner (Marcus Finn)Kai Wener (Ty Finn)Mike Henry (Dann)Anne Winters (Ensign Charly Burke)Kyra Santoro (Lieutenant Turco)Kelly Hu (Admiral Ozawa)
André Bormanis, Brannon Braga, David A. Goodman, Liz Heldens, Seth MacFarlane, Joe Menosky, Wellesley Wild, Janet Lin, Cherry Chevapravatdumrong
Set 400 years in the future, finds the crew of the U.S.S. Orville continuing their mission of exploration, as they navigate both the mysteries of the universe and the complexities of their own interpersonal relationships.